Physical activity and clustered cardiovascular disease risk factors in young children: a cross-sectional study (the IDEFICS study)

<p>Background The relevance of physical activity (PA) for combating cardiovascular disease (CVD) risk in children has been highlighted, but to date there has been no large-scale study analyzing that association in children aged ≤9 years of age. This study sought to evaluate the associations between objectively-measured PA and clustered CVD risk factors in a large sample of European children, and to provide evidence for gender-specific recommendations of PA.</p> <p>Methods Cross-sectional data from a longitudinal study in 16,224 children aged 2 to 9 were collected. Of these, 3,120 (1,016 between 2 to 6 years, 2,104 between 6 to 9 years) had sufficient data for inclusion in the current analyses. Two different age-specific and gender-specific clustered CVD risk scores associated with PA were determined. First, a CVD risk factor (CRF) continuous score was computed using the following variables: systolic blood pressure (SBP), total triglycerides (TG), total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-c) ratio, homeostasis model assessment of insulin resistance (HOMA-IR), and sum of two skinfolds (score CRFs). Secondly, another CVD risk score was obtained for older children containing the score CRFs + the cardiorespiratory fitness variable (termed score CRFs + fit). Data used in the current analysis were derived from the IDEFICS (‘Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS’) study.</p> <p>Results In boys <6 years, the odds ratios (OR) for CVD risk were elevated in the least active quintile of PA (OR: 2.58) compared with the most active quintile as well as the second quintile for vigorous PA (OR: 2.91). Compared with the most active quintile, older children in the first, second and third quintiles had OR for CVD risk score CRFs + fit ranging from OR 2.69 to 5.40 in boys, and from OR 2.85 to 7.05 in girls.</p> <p>Conclusions PA is important to protect against clustering of CVD risk factors in young children, being more consistent in those older than 6 years. Healthcare professionals should recommend around 60 and 85 min/day of moderate-to-vigorous PA, including 20 min/day of vigorous PA.</p&gt

Population and decay of C-12 states

By using the CHIMERA detector, we have measured the gamma-ray and alpha decay width of excited C-12 states important for the carbon production inastrophysical environments. For the first time, we directly observed the gamma-ray decayof the 9.64 MeV level. A gamma-ray decay width larger than previous observations wasobserved for the Hoyle state. In order to explain this enhanced yield we investigatedon the recently proposed population of an Efimov state at 7.458 MeV. The decaycharacteristics of such level are inferred

Highlights from CHIMERA Collaboration

The activities performed by the CHIMERA Collaboration since the 2018 IWM-EC workshop are outlined in this paper. Experiments performed in thelast three years and results obtained through dedicated analyses of experimentaldata already acquired are summarized. A brief report on the activities conductedat GSI is also include

The new fragment in-flight separator at INFN-LNS

An upgrade project of the Superconducting Cyclotron has been underway at INFN-LNS since 2019. One of the goals of this project is to deliver RIBs (Radioactive Ion Beams) of high intensity. To reach this aim, a dedicated facility consisting of a new fragment separator FRAISE (FRAgment In-flight SEparator) is ongoing, exploiting primary beams with a power up to approximate to 2-3 kW. The high intensity achievable with FRAISE requires the use of suitable diagnostics and tagging systems, able to operate also in a strong radioactive environment. In this framework, an R&D program has been started to develop the FRAISE facility, the diagnostics system and the tagging device; the latter will be especially useful in the CHIMERA multidetector beam line. The present contribution discusses the status of the R&D program, with particular focus on the RIBs available thanks to the use of FRAISE

Radioactive ion beam opportunities at the new FRAISE facility of INFN-LNS

At the Laboratori Nazionali del Sud of INFN (INFN-LNS) in Catania, the construction of the new Radioactive Ion Beams (RIBs) facility FRAISE (FRAgment In-flight SEparator) has reached its ending phase. The facility uses the in-flight technique based on a primary beam fragmentation impinging on light Be or C targets. FRAISE makes use of light and medium mass primary beams, having power up to asymptotic to 2-3 kW, leading to RIBs, whose intensities vary in the range of asymptotic to 10(3)-10(7) pps, for nuclei far from and close to the stability valley, respectively. FRAISE aims at providing high-intensity and high-quality RIBs for nuclear physics experiments, also serving to interdisciplinary research areas, such as medical physics. Critical aspects for high-quality beams are the tuning and transport, representing time-consuming processes and requiring dedicated diagnostics and tagging devices measuring many features of RIBs. Some of these devices should be capable to operate in radioactively activated environments because of the expected 2 kW beam lost in the dipole after the production target. Due to its peculiar robustness to radioactive damage, Silicon Carbide (SiC) technology has been considered for the detection layer. In this view, an R & D campaign has been started aiming at developing the FRAISE facility, the new diagnostics system, and a new tagging device, the latter of which will be useful for the CHIMERA multidetector beamline. In this paper, we discuss the status and the perspectives of the facility with a focus on the RIBs opportunities

Experimental investigation of α condensation in light nuclei

Background: Near-threshold α-clustered states in light nuclei have been postulated to have a structure consisting of a diffuse gas of α particles which condense into the 0s orbital. Experimental evidence for such a dramatic phase change in the structure of the nucleus has not yet been observed. Purpose: To understand the role of α condensation in light nuclei experimentally. Method: To examine signatures of this α condensation, a compound nucleus reaction using 160-, 280-, and 400-MeV 16O beams impinging on a carbon target was used to investigate the 12C(16O,7α) reaction. This permits a search for near-threshold states in the α-conjugate nuclei up to 24Mg. Results: Events up to an α-particle multiplicity of seven were measured and the results were compared to both an extended Hauser-Feshbach calculation and the Fermi breakup model. The measured multiplicity distribution exceeded that predicted from a sequential decay mechanism and had a better agreement with the multiparticle Fermi breakup model. Examination of how these 7α final states could be reconstructed to form 8Be and 12C(02+) showed a quantitative difference in which decay modes were dominant compared to the Fermi breakup model. No new states were observed in 16O, 20Ne, and 24Mg due to the effect of the N−α penetrability suppressing the total α-particle dissociation decay mode. Conclusion: The reaction mechanism for a high-energy compound nucleus reaction can only be described by a hybrid of sequential decay and multiparticle breakup. Highly α-clustered states were seen which did not originate from simple binary reaction processes. Direct investigations of near-threshold states in N−α systems are inherently impeded by the Coulomb barrier prohibiting the observation of states in the N−α decay channel. No evidence of a highly clustered 15.1-MeV state in 16O was observed from [28Si★,12C(02+)]16O(06+) when reconstructing the Hoyle state from three α particles. Therefore, no experimental signatures for α condensation were observed

Search for rare quark-annihilation decays, B --> Ds(*) Phi

We report on searches for B- --> Ds- Phi and B- --> Ds*- Phi. In the context of the Standard Model, these decays are expected to be highly suppressed since they proceed through annihilation of the b and u-bar quarks in the B- meson. Our results are based on 234 million Upsilon(4S) --> B Bbar decays collected with the BABAR detector at SLAC. We find no evidence for these decays, and we set Bayesian 90% confidence level upper limits on the branching fractions BF(B- --> Ds- Phi) Ds*- Phi)<1.2x10^(-5). These results are consistent with Standard Model expectations.Comment: 8 pages, 3 postscript figues, submitted to Phys. Rev. D (Rapid Communications

Adolescents with metabolic syndrome have a history of low aerobic fitness and physical activity levels

Abstract: Purpose: Metabolic syndrome (MS) is a clustering of cardiovascular disease risk factors that identifies individuals with the highest risk for heart disease. Two factors that may influence the MS are physical activity and aerobic fitness. This study determined if adolescent with the MS had low levels of aerobic fitness and physical activity as children. Methods: This longitudinal, exploratory study had 389 participants: 51% girls, 84% Caucasian, 12% African American, 1% Hispanic, and 3% other races, from the State of North Carolina. Habitual physical activity (PA survey), aerobic fitness (VO2max), body mass index (BMI), blood pressure, and lipids obtained at 7–10 y of age were compared to their results obtained 7 y later at ages 14–17 y. Results: Eighteen adolescents (4.6%) developed 3 or more characteristics of the MS. Logistic regression, adjusting for BMI percentile, blood pressure, and cholesterol levels, found that adolescents with the MS were 6.08 (95%CI = 1.18–60.08) times more likely to have low aerobic fitness as children and 5.16 (95%CI = 1.06–49.66) times more likely to have low PA levels. Conclusion: Low levels of childhood physical activity and aerobic fitness are associated with the presence of the metabolic syndrome in adolescents. Thus, efforts need to begin early in childhood to increase exercise

Volume, patterns, and types of sedentary behavior and cardio-metabolic health in children and adolescents: a cross-sectional study

<p>Abstract</p> <p>Background</p> <p>Cardio-metabolic risk factors are becoming more prevalent in children and adolescents. A lack of moderate-to-vigorous intensity physical activity (MVPA) is an established determinant of cardio-metabolic risk factors in children and adolescents. Less is known about the relationship between sedentary behavior and cardio-metabolic health. Therefore, the objective was to examine the independent associations between volume, patterns, and types of sedentary behavior with cardio-metabolic risk factors among children and adolescents.</p> <p>Methods</p> <p>The results are based on 2527 children and adolescents (6-19 years old) from the 2003/04 and 2005/06 National Health and Nutrition Examination Surveys (NHANES). A cardio-metabolic risk score (CRS) was calculated based on age- and sex-adjusted waist circumference, systolic blood pressure, non-high-density lipoprotein cholesterol, and C-reactive protein values. Volume and patterns of sedentary behavior and moderate-to-vigorous physical activity (MVPA) were measured objectively using accelerometers. Types of sedentary behavior were measured by questionnaire. A series of logistic regression models were used to examine associations.</p> <p>Results</p> <p>Volume and patterns of sedentary behavior were not predictors of high CRS after adjusting for MVPA and other confounders (P > 0.1). For types of sedentary behavior, high TV use, but not high computer use, was a predictor of high CRS after adjustment for MVPA and other confounders. Children and adolescents who watched ≥4 hours per day of TV were 2.53 (95% confidence interval: 1.45-4.42) times more likely to have high CRS than those who watched <1 hour per day. MVPA predicted high CRS after adjusting for all sedentary behavior measures and other confounders. After adjustment for waist circumference, MVPA also predicted high non-obesity CRS; however, the same relationship was not seen with TV use.</p> <p>Conclusion</p> <p>No association was observed between overall volume and patterns of sedentary behavior with cardio-metabolic risk factors in this large sample of children and adolescents. Conversely, high TV use and low MVPA were independently associated with cardio-metabolic risk factors. However, the association between high TV use and clustered cardio-metabolic risk factors appears to be mediated or confounded by obesity. Thus, TV and MVPA appear to be two separate behaviors that need to be targeted with different interventions and policies.</p

Metabolic Syndrome and Cardiovascular Disease after Hematopoietic Cell Transplantation: Screening and Preventive Practice Recommendations from the CIBMTR and EBMT

Metabolic syndrome (MetS) is a constellation of cardiovascular risk factors that increases the risk of cardiovascular disease, diabetes mellitus, and all-cause mortality. Long-term survivors of hematopoietic cell transplantation (HCT) have a substantial risk of developing MetS and cardiovascular disease, with an estimated prevalence of MetS of 31% to 49% among HCT recipients. Although MetS has not yet been proven to impact cardiovascular risk after HCT, an understanding of the incidence and risk factors for MetS in HCT recipients can provide the foundation to evaluate screening guidelines and develop interventions that may mitigate cardiovascular-related mortality. A working group was established through the Center for International Blood and Marrow Transplant Research and the European Group for Blood and Marrow Transplantation with the goal to review literature and recommend practices appropriate to HCT recipients. Here we deliver consensus recommendations to help clinicians provide screening and preventive care for MetS and cardiovascular disease among HCT recipients. All HCT survivors should be advised of the risks of MetS and encouraged to undergo recommended screening based on their predisposition and ongoing risk factors